background inflammatory myofibroblastic tumor is sometimes known as inflammatory pseudotumor tumor (ipt). It is a lesion of unknown etiology that has been reported in numerous anatomic sites. By definition, the tumor is composed of a dominant spindle cell proliferation with a variable inflammatory component. These spindle cells are now known to be myofibroblasts and this is the reason for the current designation for this disease. Inflammatory may not be applicable to all tumors since some investigators have demonstrated the presence of chromosomal abnormalities and documented cases showing aggressive behavior supporting the theory that at least some of these tumors are true neoplasms. The tumor is more common in women, who often present with fever of unknown origin or other vague, nonspecific symptoms. Splenomegaly is a frequent finding. Outline epidemiology   disease associations   pathogenesis   laboratory/radiologic/other diagnostic testing   gross appearance and clinical variants   histopathological features and variants   special stains/ immunohistochemistry/ electron microscopy   differential diagnosis   prognosis   treatment   commonly used terms   internet links   epidemiology characterization synonyms inflammatory pseudotumor plasma cell granuloma sex (m:f) women more common   pathogenesis characterization general   myofibroblastic tumours: neoplasias with divergent behaviour: ultrastructural and flow cytometric analysis pathol res pract 1999;195:619–632 omental-mesenteric inflammatory pseudotumor: cytogenetic demonstration of genetic changes and monoclonality in one tumor cancer 1994;73:1433–1437 epstein-barr virus hum pathol 1995;26:1093–1098. Arch pathol lab med 125:379–385, 2001 association with ebv by immunohistochemical studies in 2 of 12 cases and by in situ hybridization in 6 of 10 cases these findings corroborate with others who found an association with ebv in 4 of 6 splenic tumors and 1 of 2 liver tumors hhv-8   absence of human herpesvirus-8 in pulmonary inflammatory myofibroblastic tumor: immunohistochemical and molecular analysis of 20 cases. Tavora f, shilo k, ozbudak ih, przybocki jm, wang g, travis wd, franks tj. 1department of pulmonary and mediastinal pathology, armed forces institute of pathology, washington, dc, usa.   mod pathol. 2007 sep;20(9):995-9. Abstract quote inflammatory myofibroblastic tumors are uncommon lesions composed of spindled myofibroblasts within a variable background of collagen and inflammatory cells. cheap viagra online buy viagra online viagra online viagra without a doctor prescription buy generic viagra viagra for sale buy viagra cheap generic viagra buy viagra online Although the true nature of these lesions is not fully elucidated, identification of consistent cytogenetic alterations in the anaplastic lymphoma kinase (alk) gene suggests that they may be neoplastic. A small number of inflammatory myofibroblastic tumors have been reported to harbor human herpesvirus-8 (hhv-8), implicat.
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